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In the SURMOUNT-1 trial [16], among the pooled tirzepatide groups, there was a 7.2 mmHg reduction in systolic blood pressure with reductions in non-HDL-C and triglycerides of 9.7% and 24.8%, respectively, and increases in HDL-C of 8.0%

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Researchers concluded that this study demonstrates oral MK-677 can promote healthy bones and potentially reduce the risk of osteoporosis